Easily fabricated and recyclable Pd&Cu@Al catalyst for gram-scalephosphine-free Heck reactions with high TON

Dongliang Zhang^a,b, Zheng Wei^b, Lei Yu^a,b,*

aInstitute of Pesticide, School of Horticulture and Plant Protection, Yangzhou University

bSchool of Chemistry and Chemical Engineering, Yangzhou University

Abstract:A unique Pd&Cu@Al catalyst was easily fabricated just by immersing commercial aluminum foil in a

mixed xylene solution of PdCl2 and CuCl2. The catalyst fabrication process led to aluminum oxide coatingsin situ, which supported the metal nanoparticles and enhanced their catalytic activities for thephosphine-free Heck reaction of aryl halides and styrenes with high turnover number (TON) up to3.9×10⁵. The reaction can be scaled up to at least 100 mmol and has been applied in modification ofdrugLapatinib’s intermediate with low metal residue. This novel catalyst is of good application potentialin industrial production because it was extremely easy to be recycled, in regardless of the generation ofthe insoluble impurities or tars during the reaction processes.

Science Bulletin,2017,62,1325–1330. IF=4.000

文章连接:http://www.sciencedirect.com/science/article/pii/S209592731730484X