Practical preparation of methyl isobutyl ketone by stepwiseisopropylation reaction of acetone

Fang Wang^a,b,c, Lin Xu^a,c,d, Jiejun Huang^c, Shishi Wu^d, Lei Yu^a,c,*, Qing Xu^a,c,*,Yining Fan^d,**

aSchool of Chemistry and Chemical Engineering, Yangzhou University

bYangzhou Polytechnology Institute

cJiangsu Yangnong Chemical Group Co. Ltd.

dKey Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University

Abstract:A stepwise isopropylation reaction of acetone is developed for preparation of methyl isobutyl ketone(MIBK) through acetone condensation and a recoverable Pt/C-catalyzed transfer hydrogenation of mesityloxide (MO) with isopropanol (IPA). Almost quantitative MO conversion (up to 99.9%) and excellent MIBKselectivity (up to 99.3%) could be achieved by the method. Since IPA can be obtained from propane, acheap petrochemical product, the by-product acetone (AT) generated in the reduction of MO could beeasily recovered and reused in the preparation of MO, and the Pt/C catalyst could be recycled and reused,this H2- and waste-free reaction may be a green and practical method for preparation of the useful finechemical MIBK.

Molecular Catalysis,2017,432,99–103.

文章链接:http://sioc-journal.cn/Jwk_yjhx/CN/abstract/abstract346058.shtml