Ruthenium-catalyzed oxidative decyanative crosscoupling of acetonitriles with amines in air: ageneral access to primary to tertiary amides undermild conditions†

Yuguang Wang^a, Zhongli Wu^a,Qin Li^a, Bingchun Zhu^*,a,band Lei Yu^*,c

a Key Laboratory of Bioorganic Synthesis of Zhejiang Province,College ofBiotechnology and Bioengineering, Zhejiang University of Technology

b Zhejiang Research Institute of Chemical Industry

c School of Chemistry and Chemical Engineering, Yangzhou University

†Electronic supplementary information (ESI) available: Large pictures of reaction equipment, XRD, IR and NMR spectra of the intermediates and products.

Abstract:Catalyzed by Ru and in the presence of air and nucleophiles such as amines or ammonia, activation of theC–CN bond could be easily achieved under mild conditions to produce primary to tertiary amides in goodto excellent yields. The use of accessible and functional-group-tolerant starting materials, a cheap, lowloading and recyclable catalyst, ligand-free conditions and excellent product yields are the advantages ofthe method. Moreover, compared with the Ritter reaction and hydration methods, this novel reaction hasmore comprehensive application scope.

Catalysis Science & Technology,2017,7, 3747–3757. IF=5.773

文献链接:http://pubs.rsc.org/en/content/articlelanding/2014/cy/c7cy00761b#!divAbstract