Green and Practical Oxidative Deoximation of Oximes toKetones or Aldehydes with Hydrogen Peroxide/Air byOrganoselenium Catalysis

Xiaobi Jing^a, Dandan Yuan^a,and Lei Yu^a,*

a Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Schoolof Chemistry and Chemical Engineering, Yangzhou University

Abstract:Organoselenium-catalyzed oxidative deoximations afforded ketones and aldehydes under mildconditions. The reactions employ hydrogen peroxideand air as clean oxidants and lead to a waste-freeand metal-freedeprotection protocol for carbonylprotection strategies as well as the green synthesis ofketones and aldehydes. The mechanisms of this interesting organoselenium-catalyzed reaction have beeninvestigated by control experiments as well as the selenium 77 nuclear magnetic resonance (77Se NMR)tests. This novel reaction largely expands theapplication scope of organoselenium catalysis.

Adv. Synth. Catal.,2017,359, 1194 – 1201. IF=6.453

文章链接:http://dx.doi.org/10.1002/adsc.201601353