Highly selective sp³C–N bond activation of tertiary anilines modulated by steric and thermodynamic factors

Xiaodong Jia, *^,aPengfei Li,^bYu Shao,^cYu Yuan,^aHonghe Ji,^bWentao Hou,^bXiaofei Liu^band Xuewen Zhang^a

^aCollege of Chemistry and Chemical Engineering, Yangzhou University

^bCollege of Chemistry and Chemical Engineering, Northwest Normal University

^cSchool of Information Engineering, Yangzhou University

Abstract: A highly selective sp³C–N cleavage of tertiary anilines was achieved using the TBN/TEMPO catalyst system. When N,N-diaklylanilines (alkyl, benzyl) were employed, the N–CH₃bond was selectively cleaved via radical C–H activation. Moreover, when the allyl group was installed, totally reverse selectivity was observed. It is worth noting that the solvent effect is also crucial to obtain high reaction efficiency and selectivity.

Green Chemistry,2017,19, 5568–5574．IF = 9.125

文章链接: http://pubs.rsc.org/en/content/articlepdf/2017/gc/c7gc02775c

文章附件：文件名命名为：杂志名称简写-年份-卷-起始页码（如：GreenChem-2017-19-5568）