Platinum nanoparticle-assembled nanoflake-like tin disulfide for enzyme-based amperometric sensing of glucose

Lei Wang,1 Juan Li,1,* Yunfan Pan,1 Lingfeng Min,2 Yongcai Zhang,1 Xiaoya Hu,1 Zhanjun Yang1,*

1School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, PR China

2Clinical Medical School of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou, Jiangsu 225001, PR China

Abstract:We have prepared aplatinum nanoparticle-assemblednanoflake-likeSnS2nanocomposite of the type PtNP@SnS2 as a support forimmobilization of glucose oxidase (GOx) to obtain an electrochemical glucose biosensor based on direct electron transfer of GOx. Scanning electron microscope,transmission electron microscope, X-ray diffraction, electrochemical impedance spectroscopy, static water contact angle measurements,and cyclic voltammetry were used to characterize thenanocomposite and theglucose biosensor.The nanocomposite haslargesurface-to-volume ratio,excellent hydrophiliciy, and high electrochemical activity.This promotes the direct electron transfer between GOx and surface of a glassy carbon electrode (GCE). The GOx immobilized on the nanocomposite displays good bioactivity, and the surface coverage of modified electrode is4.15×10-11 mol·cm-2. Under optimum conditions and at a working voltage of -0.4 V vs. SCE, the glucose biosensor exhibits a linear response in the0.1to1.0mM and 1.0 to 12 mM glucose concentration ranges, with a low detection limit of 2.5μM (at an S/N ratio of 3). The biosensor shows excellent selectivity and was successfully applied to the determination of glucose in human serum samples.

Microchim. Acta, 2017, 184, 2537-2363, IF: 4.58

文章链接:https://link.springer.com/article/10.1007%2Fs00604-017-2209-0

文章附件：