Active sp³C−H Bond Oxidation Initiated sp³−sp²Consecutive C−H Functionalization of N‑Arylglycine Amides: Construction of Isatins

Honghe Ji,†Yingzu Zhu,†Yu Shao,§ Jing Liu,†Yu Yuan,*,‡and Xiaodong Jia*,†,‡

†School of Chemistry and Chemical Engineering, Yangzhou University

‡College of Chemistry and Chemical Engineering, Northwest Normal University

§School of Information Engineering,Yangzhou University

Abstract: In the presence of catalytic triarylamine radical cation, an sp³−sp²consecutive C−H functionalization of N-arylglycine amides was achieved, providing a series of isatin derivatives in high yields. In this transformation, the initial aerobic oxidation of the relatively active sp³C−H bonds triggered the following intramolecular cyclization, in which the aniline group was employed as a removable auxiliary group to enable the consecutive process.

Journal of Organic Chemistry,2017,82,9859 – 9865．IF = 4.849

文章链接: http://pubs.acs.org/doi/pdf/10.1021/acs.joc.7b01480

文章附件：文件名命名为：杂志名称简写-年份-卷-起始页码（如：JOrgChem-2017-82-9859）