A Consecutive C-H Functionalization Triggered by Oxidation of Activesp³C-H Bonds: Construction of 3,4-Dihydroquinoline-3-one Derivatives

Xiaodong Jia,^{[a], *}Wentao Hou,^[b]Yu Shao,^[c]Yu Yuan,^[a]Qian Chen,^[a]Pengfei Li,^[b]Xiaofei Liu^[b]and Honghe Ji^[b]

^aSchool of Chemistry and Chemical Engineering, Yangzhou University

^bCollege of Chemistry and Chemical Engineering, Northwest Normal University

^cSchool of Information Engineering,Yangzhou University

Abstract:We report a consecutive C-H functionalization that constructs 3,4-dihydroquinoline-3-one derivatives in high yields. This reaction is triggered by oxidation of active sp³C-H bonds of glycines and N-benzylanilines. In this radical mediated transformation, four sp³C-H bonds are functionalized efficiently, together with construction of one heterocylic ring with a quaternary carbon center.

Chemistry: A European Journal,2017,23,12980 – 12984．IF = 5.317

文章链接: http://onlinelibrary.wiley.com/doi/10.1002/chem.201702497/full

文章附件：文件名命名为：杂志名称简写-年份-卷-起始页码（如：ChemEurJ-2017-23-12980）