A Facile Construction of Quinoline-2-carboxylate Esters through An Aerobic Oxidation of Alkyl 4-Anilinocrotonates Induced by Radical Cation Salt

Xiaodong Jia*^[a], Pengfei Li,^[b]Yu Shao,^[c]Yu Yuan,^[a]Wentao Hou,^[b]Xiaofei Liu,^[b]Xuewen Zhang,^[a]and Honghe Ji^[b]

^aSchool of Chemistry and Chemical Engineering, Yangzhou University

^bCollege of Chemistry and Chemical Engineering, Northwest Normal University

^cSchool of Information Engineering,Yangzhou University

Abstract: A facile construction of quinoline-2-carboxylate esters through an aerobic oxidation of alkyl 4-anilinocrotonates was described. In the presence of dioxygen, sp³C-H bonds in 4-anilinocrotonates can easily be oxidized by catalytic radical cation salt, providing a radical intermediate. After further oxidation and domino cyclization, the desired quinoline derivatives were afforded in high yields. This reaction provided a new way to construct the pharmaceutically relevant quinoline skeleton, avoiding harsh reaction conditions and tedious starting material synthesis.

Chemistry: An Asian Journal,2017,12,1719 – 1723．IF = 4.083

文章链接: http://onlinelibrary.wiley.com/doi/10.1002/asia.201700560/epdf

文章附件：文件名命名为：杂志名称简写-年份-卷-起始页码（如：ChemAsianJ-2017-12-1719）