A dual removable activating group enabled the Povarov reaction of N-arylalanine esters: synthesis of quinoline-4-carboxylate esters

Xiaodong Jia,*^a,bShiwei Lü,^bYu Yuan,^aXuewen Zhang,^aLiang Zhang^band

Liangliang Luo^b

^aCollege of Chemistry and Chemical Engineering, Yangzhou University

^bCollege of Chemistry and Chemical Engineering, Northwest Normal University

Abstract: A dual removable activating group enabled Povarov reaction of N-arylalanine esters was reported. N-Arylalanine ester was utilized as the sole carbon source to generate N-arylimine and its tautomer, enamine, in situ by aerobic oxidation of sp³C–H bonds, and then the consecutive reaction delivered the desired quinoline-4-carboxylate esters in high yields.

Organic & Biomolecular Chemistry,2017,15, 2931–2937．IF = 3.559

文章链接: http://pubs.rsc.org/en/content/articlepdf/2017/ob/c7ob00446j?page=search

OrgBiomolChem-2017-15-2931