Cube-like CoSn(OH)6 Nanostructure for Sensitive Electrochemical Detection of H2O2 in Human Serum Sample

Yun Shu, Bing Li, Qin Xu, Peng Gu, Xiao Xiao, Fengping Liu, Liangyun Yu, Huan Pang*, Xiaoya Hu*

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China

Abstract:A novelhydrogen peroxide (H2O2) nonenzymatic electrochemical sensor was constructed based on CoSn(OH)6 nanocubes (NC). The CoSn(OH)6 nanocubes with uniform size distribution were prepared by a co-precipitation method at room temperature. Then CoSn(OH)6 NC solubilized in Nafion was immobilized on glassy carbon electrode (GCE) by the physical adsorption to determination of H2O2. The detection limit has been estimated to be 1 μM with a wide linear range from 4 to 400 µM. The as-made sensor also exhibited excellent selectivity and super stability. In addition, the sensor can be successfully applied to detect the H2O2 levels in human serum samples with satisfactory results. The high electrocatalytic activity of CoSn(OH)6 NC may be owing to the large surface area and uneven surface structure. We believe these cube-like CoSn(OH)6 nanocrystals provide a promising platform for developing nonenzymatic H2O2 sensors in biological applications.

Sensors and Actuators B: Chemical, 241, 113, 528-543. IF=4.758

文章链接:http://www.sciencedirect.com/science/article/pii/S0925400516316999