Ca(OH)2-Catalyzed Condensation of Aldehydes with Methyl ketones in Dilute Aqueous Ethanol: A Comprehensive Access to α,β-Unsaturated Ketones.

Lei Yu,* Mengting Han, Jie Luan, Lin Xu, Yuanhua Ding and Qing Xu

Jiangsu Co-Innovation Centre for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Jiangsu Key Laboratory of Zoonosis, School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, China

E-mail: yulei@yzu.edu.cn

Abstract:Cheap, abundant but seldom-employed Ca(OH)₂ was found to be an excellent low-loading (5–10 mol%) catalyst for Claisen-Schmidt condensation of aldehydes with methyl ketones under mild conditions. It was interesting that dilute aqueous ethanol (20 v/v%) was unexpectedly discovered to be the optimal solvent. The reaction was scalable at least to 100 mmol and calcium could be precipitated by CO₂and removed by filtration. Evaporation of solvent directly afforded the product in the excellent 96% yield with high purity, as confirmed by its¹H NMR spectrum.

Sci. Rep., 2016, 6, 30432

文章链接: http://www.nature.com/articles/srep30432

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