C−H Activation Relay (CHAR): An Efficient Construction of Isatin

Skeleton by Aerobic Oxidation of Glycine Esters

Xiaodong Jia,*†,‡ Yingzu Zhu,‡ Yu Yuan,† Xuewen Zhang,† Shiwei Lü,‡ Liang Zhang,‡

and Liangliang Luo‡

†College of Chemistry and Chemical Engineering, Yangzhou University

‡College of Chemistry and Chemical Engineering, Northwest Normal University

Abstract: Directed by the strategy of C−H activation relay (CHAR), an efficient construction of isatin skeleton was developed through catalytic oxidation of glycine esters. The mechanistic study reveals that the oxidation of the relatively active C−H bonds initiated the followed activation of remote and inert C−H bonds, and an intramolecular 1,6-hydrogen shift was involved as a key step.

ACS Catalysis,2016, 6 (9), 6033–6036．

文章链接:http://pubs.acs.org/doi/pdf/10.1021/acscatal.6b01781

ACSCatal-2016-6-6033