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俞磊教授在RSC Advances上发表论文
发布日期:2017-12-12 浏览次数: 字号:[ ]

Poly(N-isopropylacrylamide-co-L-proline)- catalyzed ClaisenSchmidt and Knoevenagel condensations: unexpected enhanced catalytic activity of the polymer catalyst
Hao Zhang,a,b, Mengting Han,a,b, Tian Chena, Lin Xua,b and Lei Yu *,a,b

a Institute of Pesticide, School of Chemistry and Chemical Engineering, School of Horticulture and Plant Protection, Yangzhou University
b
Jiangsu Yangnong Chemical Group Co. Ltd.
Electronic supplementary information (ESI) available: Condition optimization table, mechanism study details, product characterization, and 1H and 13C NMR spectra of the products. See DOI: 10.1039/c7ra09412d
Both authors contributed equally to this work.

Abstract: The polymer catalyst is more effective than the corresponding monomer catalyst? Yes! The prolinemodified polymer, poly(N-isopropylacrylamide-co-L-proline), was unexpectedly found to be more effective than the corresponding monomer L-proline catalyst in ClaisenSchmidt and Knoevenagel condensation reactions. 1H NMR, GC analysis and control reactions revealed that this abnormal phenomenon might be attributed to an enhanced concentration of the reactant on the surface of the polymer catalyst, which might be due to adsorption of the reactants to the polymer through hydrogenbonding of the proline moiety with the reactants. This new polymer catalyst was so robust that it could be reused at least 10 times without deactivation. The polymer-catalyzed method was rather tolerant of substrates bearing sensitive groups that are usually incompatible with conventional acid- or basecatalyzed methods, reducing the protectiondeprotection steps of the substrates.

RSC Advances, 2017, 7, 4821448221.  IF=3.108

文章链接:http://pubs.rsc.org/en/content/articlelanding/2017/ra/c7ra09412d#!divAbstract  




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